20 40 60 '''''''''|'''''''''|'''''''''|'''''''''|'''''''''|'''''''''| Sinorhizobium -MALKSFNPTTPSQRQLVIVSRAGLYKG-KPVKTLTEGLSSKGGRNNLGRITVRFQGGGH 58 Oceanobacillus -MAIKKFKPTSNGRRNMSVSDFAEITTD-TPEKSLLSPIRKRGGRNNQGKLTVRHQGGGH 58 Mesorhizobium -MALKKFNPVTPSTRQLVIVDRSGLYKG-KPVKGLTEGLTKSGGRNNYGRITARFIGGGH 58 Campylobacter -MAIKTYKPYTPSRRYITGLSSEDITAK-PSVRSLLVKLPAHAGRNSYGRITSRHKEAGA 58 Neisseria -MAIVKMKPTSAGRRGMVRVVTEGLHKG-APYAPLLEKKNSTAGRNNNGHITTRHKGGGH 58 Borrelia -MGIKTYKPKTSSLRYKTTLSFDDLSKGNDPLKSLTKGKKFKSGRDSSGRISIRRRGGGH 59 Coxiella -MALVKTKPTSPGRRFVVKVVHPELHKG-DPYAPLVESKNRINSRNNQGRITVRRRGGGH 58 Fusobacterium -MAIRKMKPITNGTRHMSRLVNDELDKV-RPEKSLTVPLKSAYGRDNYGHRTCRDRQKGH 58 Chlorobium -MAIRKLAPVTPGTRFASYAGFDEITKS-TPEKSLLVPIKRTGGRNSTGRVTSRHMGGGH 58 Prochlorococcus -MAIRTFRPYTPGTRTRVVTDFNEVTGR-KPERSLVVAKHRXKGRNNRGVITCRHRGGGH 58 Chromobacterium -MPIVKVKPTSAGRRAVVKVVNPDLHKG-APHAALVEKKNSTGGRNHNGHITTRHRGGGH 58 Geobacter -MAIKTYKPTSAGRRHQTCSAFDEITTS-TPEKSLIVTIKKTGGRNSFGRITARHIGGGH 58 Wolbachia -MGMKFFNPVTPSSRGTVLVSKVGLSKD-EPEKSLTSGKKSSGGRNNHGRITTRHRGGGH 58 Thermus -MAVKKFKPYTPSRRFMTVADFSEITKT-EPEKSLVKPLKKTGGRNNQGRITVRFRGGGH 58 Desulfovibrio -MAVRKLKPTSPGRRFQTVSDFEEITRS-TPEKSLVIGLTKKSGRNNNGRVTSRRRGGGH 58 Rhodopseudomonas -MALKTFNPTTPGQRQLVMVDRSALYKG-KPVKRLTEGKNSNGGRNNTGRITVRFRGGGH 58 Ralstonia -MALVKTKPTSPGRRSMVKVVNPDLHKG-APHAPLLEKQFQKSGRNNNGHITTRHKGGGH 58 Nitrosomonas MMALRKTKPTSPGRRAVIKSVNSFIYKG-KPFAALTEKKKKNAGRNNSGRITVRHIGGGH 59 Rhodopirellula -MGIRIYKPTSAGRRNASVSDFKELTPGYTPERSLLRPKTKTGGRNNQGKITSRHRGGGH 59 Synechococcus -MAIRNFRPYTPGTRTRVVTDFSEVTGR-KPERSLVVSKHRRKGRNNRGVITCRHRGGGH 58 Consensus MMAIXKXKPTTPGRRXXVXXXXXELXKG-XPEKSLXXXKXXXGGRNNXGRITXRHRGGGH 59 80 100 120 '''''''''|'''''''''|'''''''''|'''''''''|'''''''''|'''''''''| Sinorhizobium KRTYRLVDF-KR-R-KFDVEGTVERLEYDPNRTAFIALVNYA-DGEQAYILAPQRLAVGD 114 Oceanobacillus KRQYRIIDF-KR-D-KDGIPGRVATIEYDPNRSANIALVHYA-DGEKRYIIAPKGIKVGQ 114 Mesorhizobium KRSYRIIDF-KR-R-KFDVVGTVERIEYDPNRTAFIALIKYD-DGELSYIIAPQRLAAGD 114 Campylobacter KKLYRIIDF-KR-R-KFGIEGKVEAIEYDPYRNCRIALIAYK-DGEKRYILQPRGLSVGD 114 Neisseria KHHYRVVDF-KR-N-KDGIPAKVERIEYDPNRTAFIALLCYA-DGERRYIIAPRGIQAGA 114 Borrelia KRKYRLIDFNRR-D-KFSIPARVASIEYDPNRSANIALLVYK-DGEKRYIISPKGIKVGD 116 Coxiella KRNYRIIDF-KR-D-KEGIEGKVERLEYDPNRSAHIALVLYP-DGERRYIIAPKGVHKGS 114 Fusobacterium KRLYRIIDF-KR-N-KLDVPARVATIEYDPNRSANIALLFYV-DGEKRYILAPKGLKKGD 114 Chlorobium KRFYRIIDF-KR-N-KDNVPAKVAAIEYDPNRSARIALLHYV-DGEKRYILAPKNLKVGD 114 Prochlorococcus KRQYRLVDF-RR-N-KHGIPAKVAAIHYDPHRNARLALLFYX-DGEKRYILAPAGIXIGQ 114 Chromobacterium KKHYRLIDF-RR-N-KDGIPAKVERIEYDPNRTAHIALLCYA-DGERRYIIAPRGVKVGA 114 Geobacter KKKYRIIDF-RR-N-KVEVPAKVASIEYDPNRSARIALLHYA-DGAKRYILAPLDLKVGD 114 Wolbachia KKKYRVIDF-KR-N-RSGQ-GIVEKIEYDPNRSGFLALISYKEDDIKSYILAPQGMKPGD 114 Thermus KRLYRIIDF-KRWD-KVGIPAKVAAIEYDPNRSARIALLHYV-DGEKRYIIAPDGLQVGQ 115 Desulfovibrio KRLYRIIDF-RR-D-KAGIPAKVAHIEYDPNRTARIALLHYA-DGEKRYILAPVGIRQGD 114 Rhodopseudomonas KQAYRLVDF-KR-T-KVDVPAKVERLEYDPNRTAFIALIKYE-DGEQAYILAPQRLAVGD 114 Ralstonia KHHYRIVDF-KR-NDKDGIPAKIERLEYDPNRSANIALVLFA-DGERRYIIAPKGAVVGQ 115 Nitrosomonas KQHYRIVDF-CR-N-KDDIPAKVERIEYDPNRSAYIALLCYA-DGERRYIIAAKDIEVGS 115 Rhodopirellula KQKYRVIDF-RR-V-KDGVVATVDSVQYDPNRTARIALLKYP-DGEKHYVIAPSGVAAGD 115 Synechococcus KRLYRVVDF-RR-N-KHGITAKVAAIHYDPHRNARLALLFYA-DGEKRYILAPAGVQVGQ 114 Consensus KRXYRIIDF-KR-N-KXGIPAKVEXIEYDPNRSAXIALLXYX-DGEKRYIIAPXGJXVGD 115 140 160 180 '''''''''|'''''''''|'''''''''|'''''''''|'''''''''|'''''''''| Sinorhizobium KVIASEKAVDVKPGNAMPLQFIPVGSIIHNVEMKPGKGGQIARSAGTYAQLVGRDQGMAI 174 Oceanobacillus EIESGE-NADIKLGNALPLGSIPVGTVIHNIELKPGRGGQIARSAGAEAQILGREEKYTL 173 Mesorhizobium KIVAGE-AVDVKPGNAMPLASMPVGTIVHNIELKPGKGGQVARSAGGYAQLVGRDQGMAI 173 Campylobacter IVAAAESGLDIKPGNAMKLKNIPVGTIVHNVELKPGKGGQMIRSAGAYAQLMGKEEKYVI 174 Neisseria VLVSGA-EAAIKVGNTLPIRNIPVGTTIHCIEMKPGKGAQIARSAGASAVLLAKEGAYAQ 173 Borrelia VLESGP-NAPIKIGNALPLENIPIGRTVHNIELNVGKGGQLIRSAGGYAMILASDGNYVT 175 Coxiella KVVSGR-EAPIRPGNCLPLQNIPLGATIHNIELKPGKGAQLVRSAGASAQLAAKEGIYAI 173 Fusobacterium IVSAGS-KAEIKPGNALKLKDMPVGVQIHNIELQRGKGGQLVRSAGTAARLVAKEGTYCH 173 Chlorobium RIESGE-KVDIKVGNTMPLKNIPIGSDVHNIELKIGKGGQIARSAGAYAVLAAREGNYAT 173 Prochlorococcus ZVISGX-XVPIEXGNALPLSSIPLGSSVHCVELYAGRGGQMVRXAGSSAQLMAKEGEYVA 173 Chromobacterium VLLSGS-EAPIKAGNALPIRNIPVGTTIHCVEMQPGKGAQMVRSAGASAMLLAREGVYAQ 173 Geobacter SIVASS-NADIKPGNALPLRAIPLGTIIHNIELKIGKGGQLARSAGTFAQLMAKEGKYAQ 173 Wolbachia VVTAGN-DADILPGNCLLLKHIPVGSFVHNVELKPGNGAAIARAAGCYAQIVGRDGQYVL 173 Thermus QVVAGP-DAPIQVGNALPLRFIPVGTVVHAVELEPKKGAKLARAAGTSAQIQGREGDYVI 174 Desulfovibrio MILSGE-GADIKPGNALPMSRIPVGTNLHNIELQPGRGGQFCRAAGTYAQLVAKEGKYAL 173 Rhodopseudomonas TVIAGA-YVDVKPGNVMPLGNMPIGTIVHNVELKIGKGGQLARSAGTYAQIVGRDHDYVI 173 Ralstonia AVANGP-EAPIKAGNNLPIRNIPVGTTIHCVEILPGKGAQIARSAGTSAVLLAREGIYAQ 174 Nitrosomonas YLVSGS-SSPIKMGNAMPIRNIPVGSVIHCIELRPGKGAQLARSAGSSAQLMAKEGDYSQ 174 Rhodopirellula KLQNGP-DAPPVVGNCLPLKNIPLGTSVCCIEMRAGRGAVMCRSAGTQATLQAREADWAQ 174 Synechococcus TVVSGP-DAPIENGNAMPLSAVPLGSSVHCVELYAGRGGQMVRTAGASAQVMAKEGDYVA 173 Consensus XVXSGX-XAXIKXGNALPLXNIPVGTXVHNIELKPGKGGQJARSAGXXAQLXAREGXYAX 174 200 220 240 '''''''''|'''''''''|'''''''''|'''''''''|'''''''''|'''''''''| Sinorhizobium LRLNSGEQRLVHGSCLASIGAVSNPDHGNINDGKAGRSRWRGKRPHVRGVVMNPVDHPHG 234 Oceanobacillus VRLSSGEVRLILTTCRATIGQVGNIEHELVRVGKAGRSRWKGIRPTVRGSVMNPNDHPHG 233 Mesorhizobium LRLNSGEQRVVHGSCMATVGAVSNPDHGNINDGKAGRTVWRGKRPHNRGVTMNPVDHPHG 233 Campylobacter LRLASGEMRQVLAECMASIGEVGNEEWANVTIGKAGRNRHRGIRPQTRGSAMNPVDHPHG 234 Neisseria VRLRSGEVRKINVNCRATIGEVGNEEQSLKKIGKAGANRWRGIRPTVRGVVMNPVDHPHG 233 Borrelia VKLSSGEMRLIFKKCIATIGEIGNEDYANISIGKAGKSRWLGRRPKVRGVAMNPVDHPHG 235 Coxiella IRMRSGETRKILAVCRACIGEVSNSEHNLRSLGKAGAKRWRGRRPTVRGVAMNPVDHPHG 233 Fusobacterium VELPSGELRLIHGECMATVGEVGNSEHNLVNIGKAGRARHMGKRPHVRGAVMNPVDHPHG 233 Chlorobium LKMPSGEIRKVRIECRATIGVIGNAEHENISLGKAGRSRWLGIRPQTRGMAMNPVDHPMG 233 Prochlorococcus LKLPSTEVRLVRXECYATLGEVGNSEIRNTSLGKAGRRRWLGRRPQVRGSVMNPCDHPHG 233 Chromobacterium LRLRSGEIRLVHVDCRATVGEVGNEEHSLRKLGKAGATRWRGIRPTVRGTAMNPIDHPHG 233 Geobacter VKLPSGEVRMVLLDCMATIGQVGNIDHENVSIGKAGRSRWLGRRPKVRGVAMNPVDHPHG 233 Wolbachia LRLRSGQIRLILSSCKATIGVVSNPDHKNRKLGKAGRSRWLGIRPTVRGIAMNPVDHPHG 233 Thermus LRLPSGELRKVHGECYATVGAVGNADHKNIVLGKAGRSRWLGRRPHVRGAAMNPVDHPHG 234 Desulfovibrio LRLPSGEVRKVLAACCATVGQVGNVNHENISLGKAGRARWLGNRPKVRGVAMNPIDHPLG 233 Rhodopseudomonas LRMNSGEQRLIHGRCIAAIGAVSNPDHMNISIGKAGRKRWLGRRPHNRGVVMNPIDHPHG 233 Ralstonia VRLRSGEVRRVHIECRATIGEVGNEEHSLRQIGKAGATRWRGIRPTVRGVAMNPVDHPHG 234 Nitrosomonas IRLRSGEIRKIHISCRATIGEVSNSEHNLQSIGKAGAIRWRGVRPTVRGVAMNPIDHPHG 234 Rhodopirellula LLLPSGEVRRVPSACRATIGQVGNSDHMNIVLGKAGRSRWLGRRPHVRGTAMNPIDHPHG 234 Synechococcus LKLPSTEVRLVRRECYATLGEVGNSEVRNTSLGKAGRRRWLGRRPQVRGSVMNPCDHPHG 233 Consensus LRLXSGEXRXVXXXCXATIGEVGNXEHXNXXJGKAGRXRWLGXRPXVRGVAMNPVDHPHG 234 260 280 '''''''''|'''''''''|'''''''''|'''''''''|'''''''''|'''''' Sinorhizobium GGEGRT--SGGR-HPVTPWGKPTKGKRTR-SNKSTDKFIMRSRHQ----RKK---- 278 Oceanobacillus GGEGRA--PIGRKSPMSPWGKPTLGYKTRQRNKPSDKYIVRKRKK----------- 276 Mesorhizobium GGEGRT--SGGR-HPVSPWGKPTKGKKTR-SNKATDKFILRSRHQ----RKS---- 277 Campylobacter GGEGKK--NSGR-HPVTPWGKPTKGAKTR-RKKASDKLIISRRKG----K------ 276 Neisseria GGEGRT--GEAR-EPVSPWGTPAKGYRTR-NNKRTDNMIVRRRYS----NKG---- 277 Borrelia GGEGKT--SGGR-HPVSPWGQPTKGYKTRKKKRYSDKFIIKRRNK----------- 277 Coxiella GGEGKT--SGGR-HPVSPTGKPTKGYKTR-RNKRTSNMIIRDRRK----K------ 275 Fusobacterium GGEGKN--SVGRKSPLTPWGKPALGIKTRG-RKTSDKFIVRRRNE-----K----- 276 Chlorobium GGEGKSKSGGGRKHPKSPWGQLAKGLKTRNKKKASTKLIVRGRKA-----K----- 279 Prochlorococcus GGEGRA--PIGRAGPVTPWGKPALGLKTRKRNKPSNRFVLRKRRRXSKRSRGGRDS 287 Chromobacterium GGEGRT--GEGR-VPVSPWGTPAKGFRTR-RNKRTDNMIVRRRYS----NKG---- 277 Geobacter GGEGRT---SGGRHPVTPWGIPTKGYKTR-KNKTSTRFIVKKRSK----------- 274 Wolbachia GGEGKT--SGGR-HPVTPWGVATKGKKTRRRNKSSDKYIKQLKG------------ 274 Thermus GGEGRA---PRGRPPASPWGWQTKGLKTRKRRKPSSRFIIARRKK----------- 276 Desulfovibrio GGEGRS---SGGRHPVSPWGMPTKGYKTRDRKKASSKLIIKRRGQ-----K----- 276 Rhodopseudomonas GGEGRT--SGGR-HPVTPWGKPTKGKKTR-SNKSTDKFILISRHK----RKKK--- 278 Ralstonia GGEGKT--AAGR-DPVSPWGTPTKGYRTR-SNKRTTSMIVQRRHK----R------ 276 Nitrosomonas GGEGKT--AAGR-HPVSPWGTPSKGSRTR-KNKRTSNMIVRSRYS----KKG---- 278 Rhodopirellula GGEGRT---KGGRHPVSPSGKSAKGGRTRQKRKPSNSSIVRRRKSRRYGQLKLHK- 286 Synechococcus GGEGRA--PIGRSGPVTPWGKPALGLKTRKRNKPSNRYVLRKRRKTSKRSRGGRDS 287 Consensus GGEGRT--XXGR-HPVSPWGKPTKGXKTRXXNKXSDKXIXRXRXX----XKGGRDS 283